What question did this study set out to answer?

To synthesize novel Schiff base derivatives of 4-aminophenazone and assess their anti-inflammatory, analgesic, and antipyretic properties.

May 4, 2014Journal of Saudi Chemical SocietyOpen Access

Synthesis and biological evaluation of schiff bases of 4-aminophenazone as an anti-inflammatory, analgesic and antipyretic agent

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Authors

SMShahzad MurtazaKhwaja Fareed University of Engineering and Information Technology MAMuhammad Shoaib AkhtarInternational Islamic University, Islamabad FKFarina KanwalPakistan Council of Scientific & Industrial Research

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Implication

Preclinical study demonstrates marked anti-inflammatory, analgesic, and antipyretic actions of 4-aminophenazone Schiff bases in animal models, highlighting novel drug candidates.

Key Points

To synthesize novel Schiff base derivatives of 4-aminophenazone and assess their anti-inflammatory, analgesic, and antipyretic properties.
Synthesized Schiff base derivatives of 4-aminophenazone with various aldehydes and characterized them using 1H NMR, 13C NMR, and mass spectrometry.
Evaluated anti-inflammatory and membrane-stabilizing activities in mice via carrageenan-induced paw oedema, histamine-induced paw oedema, hypotonicity-induced haemolysis, and albumin denaturation assays.
Examined analgesic efficacy through formalin-induced paw licking and acetic acid-induced writhing, sedative properties via phenobarbitone sleeping time, and antipyretic activity against brewer’s yeast fever in rabbits.
Test compounds produced dose-dependent inhibition of paw oedema (potency: 4APZAB > 4APZBB > 4APZCB > 4APZVn), with 4APZ, 4APZAB (160 mg/kg), and 4APZVn (600 mg/kg) showing highly significant (P < 0.001) inhibition of haemolysis, and 4APZBB and 4APZCB significantly (P < 0.001) inhibiting albumin denaturation.
Analgesic assays demonstrated highly significant (P < 0.001) reductions in paw licking and writhing (potency: 4APZAB > 4APZBB > 4APZVn > 4APZCB), while 4APZVn (600 mg/kg) uniquely extended phenobarbitone-induced sleep duration.
In brewer’s yeast-induced fever models, 4APZ produced highly significant (P < 0.001) inhibition of hyperpyrexia at 1 and 2 hours, while the synthesized Schiff bases demonstrated antipyretic activity after 2, 3, and 4 hours.

Cite This Study

Murtaza et al. (2014) studied this question.

synapsesocial.com/papers/6aa720d8d4c94fa098d3b633 https://doi.org/10.1016/j.jscs.2014.04.003

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Implication

Preclinical study demonstrates marked anti-inflammatory, analgesic, and antipyretic actions of 4-aminophenazone Schiff bases in animal models, highlighting novel drug candidates.

Synthesis and biological evaluation of schiff bases of 4-aminophenazone as an anti-inflammatory, analgesic and antipyretic agent

Discussion

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Implication

Key Points

Cite This Study

Synthesis and biological evaluation of schiff bases of 4-aminophenazone as an anti-inflammatory, analgesic and antipyretic agent

Discussion

Member takes

Implication

Key Points

Cite This Study

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