Key result
Localized urokinase infusion completely recanalizes distal popliteal artery occlusion without complications in a high-risk cardiac patient.
Case Report (n=1)
Localized catheter infusion of urokinase successfully recanalized a popliteal artery occlusion originating from a left ventricular thrombus in a high-risk cardiac patient without complications.
May support catheter-directed urokinase in select high-risk cases; hypothesis-generating and requires prospective validation.
Recently streptokinase and urokinase have been shown to be useful in the nonoperative treatment of thromboembolic disease. Urokinase is emerging as a safer and more effective thrombolytic agent when applied either to definitively lyse spontaneous thrombosis where no underlying structural lesion is present or to serve as an adjunct prior to surgical reconstruction or transluminal angioplasty. The authors report a case of a high-risk cardiac patient in whom an embolic occlusion of the distal popliteal artery was completely recanalized by using a localized catheter infusion of urokinase. The source of the embolus was a left ventricular thrombus. No serious bleeding or proximal or distal embolic complications occurred. The potential hazards of fragmentation of the embolic source in the presence of systemic thrombolysis, distal trifurcation embolization, and concomitant use of heparin are reviewed.
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Weisman et al. (1988) conducted a case report in Embolic occlusion of the distal popliteal artery (n=1). Localized catheter infusion of urokinase was evaluated on Recanalization and complications. Localized catheter infusion of urokinase completely recanalized an embolic occlusion of the distal popliteal artery in a high-risk cardiac patient without serious bleeding or embolic complications.
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