Key result
Higher circulating FABP4 is linked to a ~9% greater risk of breast cancer.
Why the study?
Are circulating FABP4 and FABP5 levels associated with breast cancer in women with a family history of the disease?
Population
294 women in the oncology department with a family history of breast cancer; 198 with breast cancer, and 96…
Design
Case-control
Authors
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Hypothesis-generating for FABP4 as a risk marker in familial breast cancer; prospective studies needed before clinical consideration.
Case-Control (n=294)
Are circulating FABP4 and FABP5 levels associated with breast cancer in women with a family history of the disease?
Odds Ratio: 1.091 (95% CI 1.037–1.149)
Circulating FABP4 levels are independently associated with breast cancer, suggesting a potential role of adipose tissue and adipokines in the disease.
Guaita‐Esteruelas et al. (2017) conducted a case-control in Breast cancer (n=294). Elevated FABP4 and FABP5 levels vs. Healthy controls was evaluated on Association with breast cancer (OR 1.091, 95% CI 1.037-1.149). Higher circulating levels of FABP4 were independently associated with breast cancer (OR 1.091; 95% CI 1.037-1.149) after adjusting for age, BMI, hsCRP, non-HDLc, and triglycerides.
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