Highly efficient and general enantioselective synthesis of naturally occurring isoquinoline alkaloids

The highly efficient asymmetric synthesis of (+)-dysoxyline (three steps) and (+)-crispine A (four steps) from readily available different terminal alkynes, benzaldehyde, and 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline has been achieved, providing efficient general approaches for achieving libraries of naturally occurring chiral isoquinoline alkaloids.