Key result
Bariatric surgery and decreased mesenteric fat are linked to ~24% lower BMI and metabolic syndrome remission.
Why the study?
Central obesity increases the risk of metabolic syndrome, NAFLD, and T2DM, but the associations between changes in abdominal fat thicknesses and metabolic improvements after bariatric surgery required investigation.
Does bariatric surgery reduce mesenteric fat thickness and improve metabolic phenotypes in adults with obesity and T2DM?
Cohort (n=34)
Does bariatric surgery reduce mesenteric fat thickness and improve metabolic phenotypes in adults with obesity and T2DM?
Bariatric surgery significantly reduces mesenteric fat thickness, which is associated with the remission of metabolic syndrome, NAFLD, and T2DM at 1 year.
Mesenteric fat reduction may mark metabolic remission after bariatric surgery; hypothesis-generating and requires prospective trials to establish causality.
Obesity, especially central obesity is associated with increased risk of metabolic syndrome, non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus. The study aimed to investigate the associations of the changes of abdominal fat thicknesses with changes of anthropometric indexes and improvements of metabolic phenotypes in patients with obesity and T2DM before and after bariatric surgery. Between April 2016 and January 2017, 34 adult patients with concurrent obesity and T2DM scheduled for different bariatric surgeries were prospectively evaluated by ultrasound before and 1-year after bariatric surgery to determine abdominal fat thicknesses (mesenteric fat, preperitoneal fat and subcutaneous fat) and NAFLD. At 1 year, of the 25 patients that finished the study, significant decrease in mesenteric-fat-thickness was associated with significant reduction of obesity, that is, BMI (-24%, p < .001), remission of metabolic syndrome (32%, p = .008), NAFLD (60%, p < .001) and T2DM (44%, p < .001). Lower baseline mesenteric fat thickness was associated with remission of metabolic syndrome. Lower baseline mesenteric-fat-thickness may have the potential to predict metabolic syndrome remission after bariatric surgery.
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Chiyanika et al. (2023) conducted a cohort in Obesity and type 2 diabetes mellitus (n=34). Bariatric surgery was evaluated on Associations of changes in abdominal fat thicknesses with changes in anthropometric indexes and metabolic phenotypes. Bariatric surgery and decreased mesenteric fat thickness were associated with reduced BMI (-24%, p<0.001) and remission of metabolic syndrome (32%, p=0.008), NAFLD (60%), and T2DM (44%) at 1 year.
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