Experimental synthesis demonstrates a four-step preparation of 1-fluorocyclohexanecarboxylic acid from ketones, indicating broad utility for modulatory fluorinated prostacyclin analogs.
All articles of this category Introduction of a fluorine atom into position 16 of the ω-chain is a useful tool for modulation of biological activity in the prostanoid field. We devised a facile, four-step synthesis of 1-fluorocyclohexanecarboxylic acid, a precursor of phosphoranes and phosphonates required for building up the ω-chain of the fluorinated prostacyclin 1 . This method is generally applicable to the synthesis of α-fluoro-α-branched carboxylic acids from ketones.
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Mongelli et al. (1988) studied this question.
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