The study details the synthesis of novel fluorinated prostaglandins and prostacyclins, demonstrating their physiological effects in preclinical models including platelet aggregation inhibition and coronary artery dilation.
Novel fluorinated prostaglandins inhibit platelet aggregation and dilate coronaries in animals; leaves open human translation pending clinical trials.
The synthesis of (±)-14-fluoroPGF2α methyl ester (1), (±)-15-epi-14-fluoroPGF2α methyl ester (12), and (±)-14-fluoroprostacyclin (2) is detailed. Prostaglandins 1 and 12 have been evaluated for pregnancy interruption in the hamster and smooth muscle stimulating effects on gerbil colon and hamster uterine strips. Prostacyclin 2 was evaluated for inhibition of human blood platelet aggregation and dilation of the isolated perfused cat coronary artery.
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Grieco et al. (1978) studied this question.
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