Key result
Cyclophosphamide improves LVEF and cuts infarct area ~52% versus saline post-MI in rabbits.
Why the study?
Does cyclophosphamide or 5-fluorouracil improve cardiac function and reduce infarct area in a rabbit model of myocardial infarction?
Does cyclophosphamide or 5-fluorouracil improve cardiac function and reduce infarct area in a rabbit model of myocardial infarction?
Absolute Event Rate: 64% vs 53%
p-value: p=<0.05
Cyclophosphamide improved post-infarct cardiac function and remodeling in rabbits, associated with increased mobilization of CD34+ cells and neovascularization.
No takes yet. Share an insight, caveat, or question.
Should not change post-MI practice; leaves open whether cyclophosphamide improves remodeling in humans.
Misao et al. (2005) studied Myocardial infarction (n=48). Cyclophosphamide vs. Saline was evaluated on Left ventricular ejection fraction (LVEF) at 28 days (p=<0.05). Cyclophosphamide significantly improved left ventricular ejection fraction (64% vs 53%) and reduced old infarct area (9.2% vs 19.2%) compared to saline 28 days after myocardial infarction in rabbits.
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