Key result
Low dose cyclophosphamide significantly improved left ventricular systolic pressure compared to saline after ischemia-reperfusion injury at 24h (90 vs 64 mmHg; p<0.01).
Why the study?
Does low dose cyclophosphamide improve myocardial function in rats subjected to ischemia-reperfusion injury?
Does low dose cyclophosphamide improve myocardial function in rats subjected to ischemia-reperfusion injury?
p-value: p=<0.01
Low dose cyclophosphamide rescues cardiac function and reduces infarct size following ischemia-reperfusion injury in a rat model.
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Hypothesis-generating for immunomodulation in myocardial I/R injury; translation to clinical cardioprotection remains untested.
Zhu et al. (2008) studied Ischemia-reperfusion injury (n=72). Low dose cyclophosphamide vs. Saline was evaluated on Left ventricular systolic pressure (LVSP) (p=<0.01). Low dose cyclophosphamide significantly improved left ventricular systolic pressure compared to saline after ischemia-reperfusion injury at 24h (90 vs 64 mmHg; p<0.01).
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