Key result
Physostigmine immediately resolves post-anesthesia central anticholinergic syndrome in an 8-year-old boy.
Case Report (n=1)
Central anticholinergic syndrome should be considered as a differential diagnosis in children with prolonged sedation after general anesthesia, which can be effectively reversed with physostigmine.
Physostigmine may be trialed in suspected pediatric central anticholinergic syndrome; single case leaves open need for controlled confirmation.
We describe one of the few pediatric cases of central anticholinergic syndrome (CAS) in an 8-year-old boy undergoing elective surgery. Deep sedation, inadequate response to stimuli and reduced muscular tone of the upper airway resulting in airway obstruction were the clinical manifestations of CAS. The symptoms resolved immediately after administration of physostigmine. This case illustrates the importance of considering central anticholinergic syndrome as a differential diagnosis in children if prolonged sedation after general anesthesia occurs.
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Schultz et al. (2002) conducted a case report in Central anticholinergic syndrome (n=1). Physostigmine was evaluated on Resolution of symptoms. Administration of physostigmine immediately resolved symptoms of central anticholinergic syndrome in an 8-year-old boy presenting with prolonged sedation and airway obstruction after general anesthesia.
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