Key result
Antihypertensives and plasmapheresis improve GFR by ~38 mL/min in a malignant hypertension-induced TMA case.
Why the study?
In severe hypertension associated with TMA, establishing whether TMA is caused by malignant hypertension or conditions like TTP and HUS can be difficult.
Case Report (n=1)
In malignant hypertension-induced TMA, controlling hypertension can lead to the resolution of TMA and significant improvement in renal function over time.
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Renal recovery possible in malignant hypertension TMA with BP control plus plasmapheresis; leaves open need for controlled trials before practice change.
Bora et al. (2021) conducted a case report in Malignant hypertension-induced thrombotic microangiopathy (n=1). Antihypertensives and plasmapheresis was evaluated on Glomerular filtration rate. In a 45-year-old man with malignant hypertension-induced thrombotic microangiopathy, treatment with antihypertensives and plasmapheresis increased glomerular filtration rate from 22 to 59.5 ml/min over two years.
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