What is the clinical evidence from this study?

Study design: Cross-Sectional. Population: Atherosclerosis (n=365). Intervention: Age ≥65 years vs. Age <65 years. Primary outcome: Incidence of atherosclerotic lesions (intima-media thickness ≥ 1.5mm) (p=<0.01).

What does this research mean for the field?

The incidence of carotid atherosclerotic lesions and intima-media thickness increase significantly with age, with lesion prevalence rising sharply from 65 years of age. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To evaluate age-related changes in carotid intima-media thickness and determine the incidence of atherosclerotic lesions within a community population.

January 1, 1993Nippon Eiseigaku Zasshi (Japanese Journal of Hygiene)Open Access

The Incidence of Atherosclerotic Lesions of the Carotid Artery in People of One Community.

Q: What are the key findings of this study?

The incidence of carotid atherosclerotic lesions increased rapidly from 65 years of age, reaching 31.8% in males and 26.9% in females aged 65 or older compared to 12.8% and 9.0% in those under 65.

Q: What does this research mean for the field?

The incidence of carotid atherosclerotic lesions and intima-media thickness increase significantly with age, with lesion prevalence rising sharply from 65 years of age. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Q: What question did this study set out to answer?

To evaluate age-related changes in carotid intima-media thickness and determine the incidence of atherosclerotic lesions within a community population.

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Key result

Age 65 and older is linked to a ~170% higher incidence of carotid atherosclerotic lesions.

P<0.01
n=365

Population

365 people from one community in Niigata, Japan, who underwent carotid sonography during health examinations…

Design

Cross-sectional

Authors

SHS HayashiPublic Health Department TAToshiya AizakiNagoya University NTNaohito TanabeUniversity of Niigata Prefecture

Discussion

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Implication

Carotid sonography may index general atherosclerosis in older adults; leaves open prospective validation before screening adoption.

Key Points

To evaluate age-related changes in carotid intima-media thickness and determine the incidence of atherosclerotic lesions within a community population.
Conducted carotid sonography in 365 community residents (122 males and 243 females) during 1990 and 1991.
Measured intima-media thickness (IMT) across the main trunk and bifurcation-bulb areas of bilateral carotid arteries in 122 males, defining atherosclerotic lesions as an IMT ≥ 1.5 mm.
Average IMT was 0.8 ± 0.1 mm in the right main trunk and 0.9 ± 0.2 mm in the other three carotid regions, reaching 1.1 ± 0.3 mm at the right bifurcation in males aged ≥ 75 years.
Atherosclerotic lesion incidence rose sharply after age 65, increasing from 12.8% (10/78) to 31.8% (14/44) in males and from 9.0% (12/134) to 26.9% (29/109) in females, with bilateral lesions also increasing with age.

Study Design

Type

Cross-Sectional (n=365)

Multicenter

Structured PICO

Population

365 community-dwelling adults (66.6% female) in Japan underwent carotid sonography to assess the incidence of atherosclerotic lesions.

Outcome

Incidence of atherosclerotic lesions (defined as intima-media thickness ≥ 1.5 mm)surrogate

Main Result

Absolute Event Rate: 28.1% vs 10.4%

p-value: p=<0.01

Carotid intima-media thickness and the incidence of atherosclerotic lesions increase significantly with age, supporting the use of carotid sonography as a non-invasive index for general atherosclerosis.

Limitations

Small number of cases in each age group
Cross-sectional design limits causal inference
Did not examine factors related to lesion severity such as size or echo brightness

Cite This Study

Hayashi et al. (1993) conducted a cross-sectional in Atherosclerosis (n=365). Age ≥65 years vs. Age <65 years was evaluated on Incidence of atherosclerotic lesions (intima-media thickness ≥ 1.5mm) (p=<0.01). The incidence of carotid atherosclerotic lesions increased rapidly from 65 years of age, reaching 31.8% in males and 26.9% in females aged 65 or older compared to 12.8% and 9.0% in those under 65.

synapsesocial.com/papers/6aa741e44dacdb2248d3b060 https://doi.org/10.1265/jjh.48.966

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The Incidence of Atherosclerotic Lesions of the Carotid Artery in People of One Community.

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Main Result

Limitations

Cite This Study

The Incidence of Atherosclerotic Lesions of the Carotid Artery in People of One Community.

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Main Result

Limitations

Cite This Study

Also Consider

Also Consider