Key result
Dexmedetomidine sedation linked to 71% incidence of hemodynamic instability, especially with low baseline blood pressure.
Why the study?
What are the risk factors for hemodynamic instability in critically ill adults receiving dexmedetomidine for sedation?
Population
300 critically ill adults receiving dexmedetomidine for sedation in a noncardiac intensive care unit at Mayo…
Design
Cohort
Follow-up
24 hours
Authors
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Older critically ill adults and those with low baseline BP warrant closer monitoring on dexmedetomidine; this retrospective analysis leaves open optimal prevention strategies.
Cohort (n=300)
No
What are the risk factors for hemodynamic instability in critically ill adults receiving dexmedetomidine for sedation?
In critically ill noncardiac ICU patients, dexmedetomidine is associated with a high incidence of hemodynamic instability, particularly in older patients and those with low baseline blood pressure.
Ice et al. (2015) conducted a cohort in Critically ill adults requiring sedation (n=300). Dexmedetomidine was evaluated on Hemodynamic instability (composite of hypotension and/or bradycardia). Dexmedetomidine sedation in critically ill adults led to a 71% incidence of hemodynamic instability at 24 hours, with low baseline blood pressure (HR 2.42; 95% CI 1.68-3.49) as a key risk factor.
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