What question did this study set out to answer?

To evaluate the efficacy and toxicity of high-dose salvage chemotherapy combined with autologous bone marrow rescue in patients with recurrent or refractory primary nonseminomatous mediastinal germ cell tumors.

October 1, 1991CancerOpen Access

Salvage therapy with high-dose chemotherapy and autologous bone marrow support in the treatment of primary nonseminomatous mediastinal germ cell tumors

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To evaluate the efficacy and toxicity of high-dose salvage chemotherapy combined with autologous bone marrow rescue in patients with recurrent or refractory primary nonseminomatous mediastinal germ cell tumors.
Treated 12 patients with primary nonseminomatous mediastinal germ cell tumors who were either in second relapse or cisplatin-refractory (progression within 4 weeks of cisplatin).
Administered high-dose carboplatin (1500–1800 mg/m2) and etoposide (1200–1350 mg/m2), with ifosfamide (10 g/m2) added in two patients, supported by autologous bone marrow rescue across two planned cycles.
Only 5 of 12 patients received both planned rounds due to excessive toxicity in 4 patients and inadequate response in 3 patients.
Treatment-related mortality was high, with 4 peritransplant deaths caused by sepsis (n=2) or bleeding (n=2).
No patient achieved a complete remission, resulting in 6 partial remissions, 4 cases of stable disease, and 2 cases of progressive disease, with a median overall survival of 107 days (range, 14 to 347 days).

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Implication

Clinical series reveals poor survival and high toxicity of high-dose salvage chemotherapy in refractory mediastinal germ cell tumors, indicating this regimen is ineffective.

Cite This Study

Broun et al. (1991) studied this question.

synapsesocial.com/papers/6aa74c281e479256cc188b10 https://doi.org/10.1002/1097-0142(19911001)68:7<1513::aid-cncr2820680708>3.0.co;2-8

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Implication

Clinical series reveals poor survival and high toxicity of high-dose salvage chemotherapy in refractory mediastinal germ cell tumors, indicating this regimen is ineffective.

Salvage therapy with high-dose chemotherapy and autologous bone marrow support in the treatment of primary nonseminomatous mediastinal germ cell tumors

Key Points

Discussion

Implication

Cite This Study

Salvage therapy with high-dose chemotherapy and autologous bone marrow support in the treatment of primary nonseminomatous mediastinal germ cell tumors

Key Points

Discussion

Implication

Cite This Study

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