Key result
Low serum 25(OH)D linked to ~360% higher odds of endothelial dysfunction in poorly controlled T2D.
Why the study?
The association between serum 25-hydroxyvitamin D levels and vascular endothelial function in patients with type 2 diabetes required determination.
Is low serum 25(OH)D associated with vascular endothelial dysfunction in patients with poorly controlled type 2 diabetes?
Observational (n=113)
No
Is low serum 25(OH)D associated with vascular endothelial dysfunction in patients with poorly controlled type 2 diabetes?
Odds Ratio: 4.598 (95% CI 1.961–10.783)
Absolute Event Rate: 67.9% vs 31.6%
p-value: p=<0.001
Low serum vitamin D levels (<16.5 ng/mL) are significantly associated with vascular endothelial dysfunction in patients with poorly controlled type 2 diabetes.
Supports further investigation of vitamin D in T2D endothelial dysfunction; does not justify supplementation without RCTs.
AIM: This study aimed to determine the association between serum 25-hydroxyvitamin D (25(OH)D) levels and vascular endothelial function in patients with type 2 diabetes (T2D). METHODS: This retrospective study included 113 patients with poorly controlled T2D who were admitted for in-hospital diabetes educational program and underwent measurements of serum 25(OH)D levels and reactive hyperemia index (RHI). RESULTS: Serum 25(OH)D levels significantly correlated with RHI in T2D patients. Receiver operating characteristic (ROC) curve analysis showed that serum 25(OH)D level of 16.5 ng/mL is the optimal cutoff level for predicting vascular endothelial dysfunction (RHI＜1.67), with a sensitivity of 68.5%, specificity of 67.9%, and area under the ROC curve of 0.668 (95% confidence interval [CI]: 0.566-0.770, p=0.002). The mean RHI was significantly lower (1.70±0.54) in patients with low 25(OH)D levels (n=56, 25(OH)D levels ＜16.5 ng/mL) than that (1.99±0.58; p＜0.001) in patients with high 25(OH)D levels (n=57, 25(OH)D level ≥ 16.5 ng/mL). The proportion of patients with RHI＜1.67 was higher in the low 25(OH)D group than in the high 25(OH)D group (38% vs. 18%; p＜0.001). Multivariate logistic regression analysis identified that serum 25(OH)D level ＜16.5 ng/mL was associated with increased odds of RHI ＜1.67 (odds ratio 4.598, 95% CI 1.961-10.783, p＜0.001). CONCLUSION: The results demonstrated the association of serum 25(OH)D levels with endothelial function in poorly controlled T2D patients and identified serum 25(OH)D level of ＜16.5 ng/mL as a predictor of RHI ＜1.67. Serum 25(OH)D level is a potentially useful marker of vascular endothelial dysfunction in poorly controlled T2D patients.
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Tanaka et al. (2021) conducted an observational in Poorly controlled type 2 diabetes (n=113). Low serum 25(OH)D levels (<16.5 ng/mL) vs. High serum 25(OH)D levels (≥16.5 ng/mL) was evaluated on Vascular endothelial dysfunction (Reactive Hyperemia Index < 1.67) (OR 4.598, 95% CI 1.961-10.783, p=<0.001). Low serum 25(OH)D levels (<16.5 ng/mL) were independently associated with increased odds of vascular endothelial dysfunction (OR 4.598) in patients with poorly controlled type 2 diabetes.
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