Why the study?
Does early initiation of intravenous thrombolytic therapy prior to helicopter transport improve infarct vessel patency and is it safe in patients with evolving myocardial infarction?
Population
150 consecutive patients with acute myocardial infarction transported by helicopter for acute intervention
Comparison
Intravenous thrombolytic therapy initiated prior… vs No thrombolytic therapy prior to transfer
Design
Cohort
Follow-up
Immediate (during transit and upon arrival for angiography)
Key result
Early initiation of intravenous thrombolytic therapy prior to helicopter transfer for acute MI was associated with increased infarct vessel patency (61.8% vs 31.6%; p<0.001).
Authors
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Supports pre-transfer thrombolysis for higher patency in acute MI; hypothesis-generating and requires randomized confirmation before practice change.
Cohort (n=150)
Does early initiation of intravenous thrombolytic therapy prior to helicopter transport improve infarct vessel patency and is it safe in patients with evolving myocardial infarction?
Absolute Event Rate: 61.8% vs 31.6%
p-value: p=<0.001
Helicopter transfer of patients with evolving myocardial infarction is safe, and early out-of-hospital thrombolytic therapy improves infarct vessel patency without causing dangerous transport complications.
Topol et al. (1986) conducted a cohort in acute myocardial infarction (n=150). Intravenous thrombolytic therapy vs. No thrombolytic therapy was evaluated on Infarct vessel patency on immediate coronary angiography (p=<0.001). Early initiation of intravenous thrombolytic therapy prior to helicopter transfer for acute MI was associated with increased infarct vessel patency (61.8% vs 31.6%; p<0.001).
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