Key result
Androgen receptor knockout in male mice aggravates doxorubicin-induced cardiotoxicity, reducing survival and LV function.
Why the study?
Does the androgen receptor counteract doxorubicin-induced cardiotoxicity in male mice?
Population
Male AR knockout and age-matched littermate male wild-type mice at 25 wk of age, and cardiac myoblast cells
Comparison
Doxorubicin (Dox) 20 mg/kg ip injection vs Vehicle ip injection
Design
Preclinical
Authors
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AR may protect against doxorubicin cardiotoxicity in models; leaves open clinical translation or therapeutic targeting.
Does the androgen receptor counteract doxorubicin-induced cardiotoxicity in male mice?
The androgen-androgen receptor system counteracts doxorubicin-induced cardiotoxicity in male mice by activating the Akt pathway and up-regulating Tfam to protect against mitochondrial damage and apoptosis.
Ikeda et al. (2010) studied Doxorubicin-induced cardiotoxicity. Androgen receptor knockout (ARKO) vs. Wild-type (WT) mice was evaluated on Survival rate and left ventricular function. Androgen receptor knockout in male mice aggravated doxorubicin-induced cardiotoxicity, reducing survival and left ventricular function compared to wild-type mice.
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