Key result
Type D personality is linked to ~60% higher active IBD risk, driven by depressive symptoms.
Why the study?
Inflammatory bowel disease can be exacerbated by stress and depression, and Type D personality is associated with adverse outcomes in coronary heart disease, but its prevalence and relationship to disease course in IBD were unclear.
Is Type D personality associated with depressive symptoms and future active disease in patients with inflammatory bowel disease?
Cohort (n=2,275)
Is Type D personality associated with depressive symptoms and future active disease in patients with inflammatory bowel disease?
Answers are grounded in this paper and cite their sources.
Type D personality is prevalent in IBD patients and is strongly associated with depressive symptoms, which largely mediate its association with future active disease.
BACKGROUND: Inflammatory bowel disease (IBD) can be exacerbated by stress and depression. Type D personality, characterised by high negative affectivity and social inhibition, represents a vulnerability towards stressors and is associated with adverse outcomes in coronary heart disease. AIMS: To assess the prevalence of Type D personality in IBD patients and investigate potential associations with disease course. METHODS: We tested for associations between Type D (Type D Scale-14), depressive symptoms (Hospital Anxiety and Depression Scale's depression subscore ≥11) and recurrent IBD amongst Swiss IBD cohort patients. We built regression models for cross-sectional and Cox proportional hazards models for time-to-event analyses. IBD disease course was assessed by the future occurrence of active disease (Crohn's Disease Activity Index ≥150/Modified Truelove & Witts activity index ≥10) and several IBD-relevant endpoints. RESULTS: Amongst 2275 patients (1005 ulcerative colitis, 1270 Crohn's disease), 672 (29.5%) had Type D. Type D was a significant risk factor for future active disease (adjusted hazard ratio, aHR: 1.60, corrected P value, q = 0.007) and predicted the future presence of depressive symptoms (aHR: 3.30, P < 0.001). The combination of Type D and depressive symptoms further increased the risk for active disease (aHR: 3.98, q < 0.001). However, Type D associated depressive symptoms seemed to be the main contributor to this effect as Type D's predictive power decreased considerably in models corrected for depressive symptoms (aHR: 1.32, CI: 0.97-1.79, q = 0.292). CONCLUSIONS: Type D personality's prevalence amongst IBD patients was comparable with its prevalence in the general population. Type D was strongly associated with depressive symptoms and showed modest independent associations with IBD prognosis.
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Jordi et al. (2021) conducted a cohort in Inflammatory bowel disease (n=2,275). Type D personality vs. Without Type D personality was evaluated on Future occurrence of active disease (aHR 1.60, p=q = 0.007). Type D personality was a significant risk factor for future active disease in patients with inflammatory bowel disease (aHR 1.60; q=0.007), an effect largely driven by associated depressive symptoms.
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