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Surendra M. Bahala, Jamie M. Romanskya & Francisco J. Alvarezaa Pharmaceutical Research & Development, Bristol-Myers Squibb Comapany, WilmingtonUSAAqueous liquid formulations of efavirenz, a nonnucleoside inhibitor of reverse transcriptase, have prolonged burning (peppery) taste. Medium-chain triglycerides (MCT) was used as the vehicle to mask the taste and obtain palatable oral liquid formulations containing 20 mg/mL efavirenz. The use of MCT for enhancement of palatability and stability is recommended for drugs that show high solubility and partitioning in this vehicle.
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Bahal et al. (2003) studied this question.
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