Key result
Transapical Tiara mitral valve implantation achieves stable positioning and normal function in 2 high-risk patients.
Why the study?
Is the Tiara transapical mitral valve implantation system feasible and effective for treating severe mitral regurgitation in high-risk patients?
Case Report (n=2)
No
Is the Tiara transapical mitral valve implantation system feasible and effective for treating severe mitral regurgitation in high-risk patients?
Initial preclinical and first-in-human experiences suggest the Tiara transapical mitral valve implantation system is a feasible alternative for high-risk patients with severe mitral regurgitation.
Hypothesis-generating for transapical Tiara use in high-risk mitral regurgitation; prospective trials needed before clinical adoption.
Mitral valve surgery is the gold standard therapy for severe mitral regurgitation, but can be associated with significant morbidity and mortality. Percutaneous mitral leaflet repair has recently been established as a viable alternative to surgery, but many patients are ineligible and repair may not be optimal. Transcatheter mitral valve implantation may be an alternate therapeutic option, particularly for high-risk patients. We outline the initial preclinical and first-in-human experience with the Tiara transapical mitral valve implantation system, highlighting the ease of implantation, proven feasibility and excellent haemodynamic performance.
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Cheung et al. (2014) conducted a case report in Severe mitral regurgitation (n=2). Tiara transcatheter mitral valve implantation system was evaluated on Procedural success and valve function. Transapical implantation of the Tiara transcatheter mitral valve was successfully performed in two high-risk patients, demonstrating stable positioning, normal valve function, and no left ventricular outflow tract obstruction.
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