What question did this study set out to answer?

To evaluate the genetic and clinical divergence between Salmonella Typhimurium ST313 isolates causing gastrointestinal illness in the UK and those responsible for invasive infections in sub-Saharan Africa.

May 18, 2017Open Access

Salmonella enterica serovar Typhimurium ST313 responsible for gastroenteritis in the UK are genetically distinct from isolates causing bloodstream infections in Africa

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Authors

PAPhilip AshtonUniversity of Liverpool SOSiân V. OwenNew York State Department of Health LKLukeki KaindamaPublic Health England

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Implication

Genomic surveillance study reveals distinct Salmonella Typhimurium ST313 lineages in the UK and Africa, indicating niche specialization driven by accessory genome elements.

Key Points

To evaluate the genetic and clinical divergence between Salmonella Typhimurium ST313 isolates causing gastrointestinal illness in the UK and those responsible for invasive infections in sub-Saharan Africa.
Analyzed routine whole-genome sequencing data from 2,888 S. Typhimurium patient isolates collected by Public Health England in England and Wales.
Conducted phylogenetic reconstruction and Bayesian evolutionary analysis to determine lineage ancestry, pseudogene distribution, and accessory genome contents.
Identified ST313 in 2.7% (79/2888) of UK isolates; extra-intestinal isolation was strongly linked to travel to Africa (OR 12 [95% CI: 3, 53]).
Demonstrated that UK gastroenteritis isolates represent previously unsampled genetic diversity that is phylogenetically distinct from invasive African ST313 lineages, which diverged from common ancestors circa 1796 and 1903.
Found that African lineages uniquely harbor specific prophages and drug-resistance elements, including a chromosomally integrated bla CTX-M-15 gene, while sharing most pseudogenes with UK lineages (only 10 of 44 pseudogenes were specific to African lineage 2).

Cite This Study

Ashton et al. (2017) studied this question.

synapsesocial.com/papers/6aa76977e688c779dc0ad2f7 https://doi.org/10.1101/139576

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Implication

Genomic surveillance study reveals distinct Salmonella Typhimurium ST313 lineages in the UK and Africa, indicating niche specialization driven by accessory genome elements.

Salmonella enterica serovar Typhimurium ST313 responsible for gastroenteritis in the UK are genetically distinct from isolates causing bloodstream infections in Africa

Discussion

Member takes

Implication

Key Points

Cite This Study

Salmonella enterica serovar Typhimurium ST313 responsible for gastroenteritis in the UK are genetically distinct from isolates causing bloodstream infections in Africa

Discussion

Member takes

Implication

Key Points

Cite This Study

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