What question did this study set out to answer?

To dissect the specific nutritional drivers of environmental enteropathy by characterizing metabolic and intestinal microbiota alterations caused by isolated zinc or protein deficiency in weaned mice.

October 12, 2016American Journal of Clinical NutritionOpen Access

Protein- and zinc-deficient diets modulate the murine microbiome and metabolic phenotype

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Authors

JMJordi Mayneris‐PerxachsInstitut d'Investigació Biomèdica de Girona DBDavid T. BolickUniversity of Virginia JLJoy LengUniversity of Liverpool

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Implication

Animal study demonstrates that dietary protein deficiency alters gut microbiota maturation and systemic metabolism in weaned mice, highlighting metabolic mechanisms of environmental enteropathy.

Key Points

To dissect the specific nutritional drivers of environmental enteropathy by characterizing metabolic and intestinal microbiota alterations caused by isolated zinc or protein deficiency in weaned mice.
Weaned mice were maintained on zinc-deficient, protein-deficient, or control diets for up to 24 days postweaning.
Metabolic profiles and fecal microbiota compositions were characterized independently using 1H nuclear magnetic resonance spectroscopy and 16S rRNA gene sequencing.
Protein restriction arrested normal microbiota maturation by retaining pre-weaning Bacteroidetes profiles, whereas zinc-deficient microbiota profiles remained comparable to well-nourished controls.
Protein deficiency stunted growth and markedly disrupted energy, polyamine, and purine and pyrimidine metabolism, alongside reduced microbial proteolysis and increased microbial choline processing.
Verrucomicrobia, predominantly Akkermansia muciniphila, increased dramatically by day 14 postweaning in both control and protein-deficient cohorts.

Cite This Study

Mayneris‐Perxachs et al. (2016) studied this question.

synapsesocial.com/papers/6aa76a93f20ff35e0384b5c8 https://doi.org/10.3945/ajcn.116.131797

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Implication

Animal study demonstrates that dietary protein deficiency alters gut microbiota maturation and systemic metabolism in weaned mice, highlighting metabolic mechanisms of environmental enteropathy.

Protein- and zinc-deficient diets modulate the murine microbiome and metabolic phenotype

Discussion

Member takes

Implication

Key Points

Cite This Study

Protein- and zinc-deficient diets modulate the murine microbiome and metabolic phenotype

Discussion

Member takes

Implication

Key Points

Cite This Study

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