Biphasic Effects of D3-Receptor Agonists, 7-OH-DPAT and PD128907, on the D1-Receptor Agonist-Induced Hyperactivity in Mice

Effects of D3-receptor agonists, 7-OH-DPAT and PD128907, on the D1-receptor agonist SKF81297-induced hyperactivity in mice were examined. 7-OH-DPAT and PD128907 significantly suppressed the SKF81297-induced hyperactivity at low doses, but significantly potentiated the hyperactivity at high doses. These D3-agonists alone had no effect on the motor activity. A kappa-receptor agonist that reduces dopamine release had no effect on the SKF81297-induced hyperactivity. These results suggest that lower doses of 7-OH-DPAT and PD128907 may negatively influence the D1-receptor mediated behaviors via post synaptic D3-receptors. On the other hand, higher doses of these compounds may positively influence these behaviors via D2- or D3-receptors.