Key result
Infection and treatment problems were the leading precipitating factors for diabetic ketoacidosis, which had an 11.3% in-hospital mortality rate associated with older age (P=0.004).
Why the study?
What are the precipitating factors, outcomes, and recurrence rates of diabetic ketoacidosis in a university hospital in Damascus?
Observational (n=100)
No
What are the precipitating factors, outcomes, and recurrence rates of diabetic ketoacidosis in a university hospital in Damascus?
In a Syrian university hospital, DKA was most commonly precipitated by infection and associated with an 11.3% in-hospital mortality rate driven by underlying illness severity in older patients.
Single-center retrospective DKA data from Syria are hypothesis-generating; prospective studies needed to confirm recurrence and outcomes.
AIMS: To study precipitating factors, outcomes, and recurrence of diabetic ketoacidosis (DKA) at a University hospital at Damascus, the capital of Syria. PATIENTS AND METHODS: Medical records between 2006 and 2012 were reviewed. One hundred and fifteen admissions for 100 patients with DKA were included. All fulfilled the American Diabetic Association DKA diagnostic criteria. RESULTS: Of 115 admissions of DKA, there were 92 single admission and 23 recurrent admissions (eight patients). The order of precipitating factors of recurrent DKA or single admissions were the same with different percentage. The first and second factors were infection (74% and 48%) and treatment problems (17% and 24%), respectively. Complications rate was significantly higher in the intensive care unit (41.6%), compared to the ward admissions (14.2%). Overall in-hospital mortality rate was 11.3%. The severity of medical conditions that provoke DKA with aging, not the metabolic complications of hyperglycemia or ketoacidosis, were behind this high mortality rate. Patients who died were significantly (P = 0.004) older than patients who were discharged alive. CONCLUSION: Results concerning precipitating factor were similar to the results of many other studies. However, mortality rate was higher which might be explained by the severity of underlying precipitating illness.
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Alourfi et al. (2015) conducted an observational in Diabetic ketoacidosis (n=100). Diabetic ketoacidosis was evaluated on Precipitating factors, outcomes, and recurrence. Infection and treatment problems were the leading precipitating factors for diabetic ketoacidosis, which had an 11.3% in-hospital mortality rate associated with older age (P=0.004).
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