Key result
CRISPR-Cas systems regulate endogenous gene expression and enable targeted synthetic gene control.
This review highlights the expanding utility of CRISPR-Cas systems beyond DNA cleavage, demonstrating their potential as versatile tools for targeted gene regulation.
CRISPR versatility for gene regulation may aid research; leaves open clinical translation in cardiology pending validation.
Clustered regularly interspaced short palindromic repeats (CRISPR) loci and their associated cas (CRISPR-associated) genes provide adaptive immunity against viruses (phages) and other mobile genetic elements in bacteria and archaea. While most of the early work has largely been dominated by examples of CRISPR-Cas systems directing the cleavage of phage or plasmid DNA, recent studies have revealed a more complex landscape where CRISPR-Cas loci might be involved in gene regulation. In this review, we summarize the role of these loci in the regulation of gene expression as well as the recent development of synthetic gene regulation using engineered CRISPR-Cas systems.
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Bikard et al. (2013) reported a review. CRISPR-Cas systems was evaluated. CRISPR-Cas systems, traditionally known for adaptive immunity, can also regulate endogenous gene expression and be engineered for targeted synthetic gene control.
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