Key result
Chemotherapy and radiotherapy provide brief hemodynamic improvement in mediastinal synovial sarcoma before death at 2 months.
Case Report (n=1)
This case highlights the rapid progression and poor prognosis of mediastinal monophasic synovial sarcoma with pericardial extension despite chemoradiotherapy.
Chemoradiotherapy yields only transient hemodynamic benefit in mediastinal monophasic synovial sarcoma; leaves open the search for effective therapies in this rare, aggressive entity.
A 46-year-old man presented with mass on chest x-ray along with a 6-month history of weight loss, dyspnea and cough. He was hypotensive and an echocardiogram showed large extra-cardiac mass compressing the right ventricular outflow tract resulting in features of cardiac tamponade. Chest computed tomography revealed a mediastinal mass invading the pericardium adjacent to right ventricular outflow tract. Biopsy of the mass confirmed primary monophasic synovial sarcoma. Chemotherapy and radiotherapy along with anti-inflammatories were given as surgery was too high risk due to the location of the tumour and pericardial involvement. Patient responded briefly to the treatment with improvement in hemodynamic parameters but over next weeks he became less responsive to treatment with increasing size. He died 2 months after treatment commenced.
No takes yet. Share an insight, caveat, or question.
Khan et al. (2018) conducted a case report in Mediastinal monophasic synovial sarcoma with pericardial extension (n=1). Chemotherapy, radiotherapy, and anti-inflammatories was evaluated on Patient survival and response to treatment. Chemotherapy and radiotherapy provided brief hemodynamic improvement in a patient with mediastinal monophasic synovial sarcoma, but the patient died 2 months after treatment commenced.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: