Key result
Dextran volume loading fails to increase stroke volume index in patients with RV dysfunction.
Why the study?
Does volume loading with dextran infusion alter right ventricular filling dynamics measured by Doppler echocardiography in patients with ischemic heart disease?
Population
31 subjects, comprising 7 normal subjects and 24 patients with ischemic heart disease. The ischemic heart…
Comparison
Volume loading via dextran infusion vs Baseline and comparison across groups with…
Design
Cohort
Authors
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Volume loading may not augment output in RV dysfunction; supports Doppler assessment of diastolic filling as a marker in ischemic heart disease.
Observational (n=31)
Does volume loading with dextran infusion alter right ventricular filling dynamics measured by Doppler echocardiography in patients with ischemic heart disease?
Effect estimate: r=0.56
p-value: p=>0.01
Pulsed Doppler echocardiography during volume loading is a useful non-invasive method to demonstrate right ventricular diastolic dysfunction in patients with ischemic heart disease.
Odake et al. (1991) conducted an observational in Ischemic heart disease (n=31). Volume loading (dextran infusion) vs. Normal subjects and baseline was evaluated on Correlation between percent change of R(T) and delta SVI / delta RAP (r=0.56, p=>0.01). Volume loading with dextran infusion did not increase stroke volume index in patients with right ventricular dysfunction, correlating with unchanged early diastolic filling (r=0.56, p>0.01).
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