Key result
Helicobacter pylori eradication, warfarin, and tranexamic acid successfully treat prolonged thrombocytopenia and DIC after aortic surgery.
Case Report (n=1)
Multidisciplinary management, including H. pylori eradication and coagulation optimization, may be necessary for prolonged DIC associated with aortic aneurysm even after successful surgery.
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May support considering H. pylori eradication in refractory post-aneurysm DIC; hypothesis-generating and requires prospective validation.
We report a case of an infrarenal abdominal aortic aneurysm that developed acute onset thrombocytopenia and disseminated intravascular coagulation (DIC) after a previous coronary artery bypass grafting. Open surgical intervention was successfully performed for the treatment of aortic aneurysm; however, thrombocytopenia and enhanced-fibrinolytic-type DIC were prolonged even after the surgery, and improved after Helicobacter pylori eradication therapy and medication with warfarin and oral tranexamic acid. Surgical intervention alone was not effective as a treatment for DIC associated with aortic aneurysm, and multidisciplinary management was necessary for the optimization of the coagulation and fibrinolytic systems, even after successful surgery.
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Yamamoto et al. (2022) conducted a case report in Abdominal aortic aneurysm with disseminated intravascular coagulation and thrombocytopenia (n=1). Open surgical intervention followed by Helicobacter pylori eradication therapy, warfarin, and oral tranexamic acid was evaluated on Resolution of thrombocytopenia and DIC. Prolonged thrombocytopenia and DIC after aortic aneurysm surgery were successfully treated with Helicobacter pylori eradication therapy, warfarin, and oral tranexamic acid.
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