Key result
Subcutaneous dalteparin relieves symptoms and improves coagulopathy in chronic post-AAA DIC.
Why the study?
Chronic disseminated intravascular coagulation after abdominal aortic aneurysm surgery requires effective symptomatic and haemostatic management strategies.
Does dalteparin improve symptoms and hematologic parameters in a patient with chronic DIC after abdominal aortic aneurysm repair?
Case Report (n=1)
Does dalteparin improve symptoms and hematologic parameters in a patient with chronic DIC after abdominal aortic aneurysm repair?
Long-term treatment with low-molecular-weight heparin (dalteparin) can provide good symptomatic control of chronic DIC associated with abdominal aortic aneurysm.
May support symptomatic control with LMWH in rare chronic DIC; leaves open need for prospective trials to confirm benefit and safety.
A 77-year-old man developed chronic disseminated intravascular coagulation (DIC) after surgical repair of a large infrarenal aortic aneurysm. Self-administered subcutaneous dalteparin therapy (5000 units o.d.) led to rapid relief of symptoms and sustained improvements in his platelet count and fibrinogen level; activation of coagulation and fibrinolysis appeared to be relatively unaffected. Long-term treatment with low-molecular-weight heparin can provide good symptomatic control of chronic DIC associated with abdominal aortic aneurysm.
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Cummins et al. (2001) conducted a case report in chronic disseminated intravascular coagulation (DIC) (n=1). dalteparin was evaluated on relief of symptoms and improvements in platelet count and fibrinogen level. Self-administered subcutaneous dalteparin therapy led to rapid relief of symptoms and sustained improvements in platelet count and fibrinogen level in a patient with chronic DIC after AAA surgery.
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