Key result
Rivaroxaban successfully manages chronic DIC linked to AAA and NVAF in an outpatient setting.
Why the study?
Does rivaroxaban improve chronic DIC associated with an abdominal aortic aneurysm in a patient with non-valvular atrial fibrillation?
Case Report (n=1)
No
Does rivaroxaban improve chronic DIC associated with an abdominal aortic aneurysm in a patient with non-valvular atrial fibrillation?
Rivaroxaban may be an effective treatment option for managing chronic disseminated intravascular coagulation associated with an abdominal aortic aneurysm.
Answers are grounded in this paper and cite their sources.
May support rivaroxaban for chronic DIC in AAA with AF; leaves open need for prospective trials.
A 67-year-old man with non-valvular atrial fibrillation (AF) and previous myocardial and cerebral infarctions had uncontrollable bleeding after undergoing dental extraction because of an exacerbation of chronic disseminated intravascular coagulation (DIC) due to an abdominal aortic aneurysm. After successful treatment of the bleeding with the transfusion of fresh frozen plasma and platelets, nafamostat mesilate was used to treat the chronic DIC. Finally, rivaroxaban (an oral direct Factor Xa inhibitor) was prescribed for chronic DIC, as well as non-valvular AF. Following the initiation of rivaroxaban, the chronic DIC gradually improved, and the patient was discharged.
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Kawano et al. (2015) conducted a case report in Disseminated intravascular coagulation (DIC) associated with abdominal aortic aneurysm (n=1). Rivaroxaban was evaluated on Improvement of chronic DIC and prevention of rebleeding. Rivaroxaban successfully managed chronic disseminated intravascular coagulation associated with an abdominal aortic aneurysm and non-valvular atrial fibrillation in an outpatient setting.
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