Key result
Administration of edoxaban led to marked improvement of disseminated intravascular coagulation caused by aortic dissection without serious adverse events.
Why the study?
Does edoxaban improve DIC status in a patient with aortic dissection?
Case Report (n=1)
No
Does edoxaban improve DIC status in a patient with aortic dissection?
Edoxaban may be an effective treatment for disseminated intravascular coagulation caused by aortic dissection.
Should not yet change practice for aortic dissection-associated DIC; hypothesis-generating case report requiring prospective trials.
A 70-year-old woman was hospitalized for exacerbation of chronic idiopathic thrombocytopenic purpura (ITP) and disseminated intravascular coagulation (DIC) from old aortic dissection. Initially, we increased the dose of prednisolone for ITP. However, her bleeding tendency caused by DIC worsened despite the rapid recovery of her platelet count, and the required amount of fresh-frozen plasma for transfusion increased. The administration of edoxaban for atrial fibrillation led to the marked improvement of her DIC status without serious adverse events. This case suggests that a direct oral anticoagulant may be an effective treatment for DIC caused by aortic dissection.
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Uemura et al. (2020) conducted a case report in Disseminated Intravascular Coagulation (DIC) and Immune Thrombocytopenic Purpura (ITP) (n=1). Edoxaban was evaluated on Improvement of DIC status. Administration of edoxaban led to marked improvement of disseminated intravascular coagulation caused by aortic dissection without serious adverse events.
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