September 18, 2001Circulation
Clinical and Angiographic Effects of Chronic Calcium Channel Blocker Therapy Continued Beyond First Postoperative Year in Patients With Radial Artery Grafts
Key result
Continuing diltiazem beyond one year post-op fails to improve 5-year radial artery graft patency or outcomes.
- n=120
Why the study?
Does the continuation of chronic calcium channel blocker therapy beyond the first postoperative year improve clinical outcomes or radial artery graft patency in patients with radial artery grafts?
Population
120 patients who received radial artery grafts for myocardial revascularization and at 1 year post-operation…
Comparison
Continuation of chronic calcium channel blocker… vs Suspension of chronic calcium channel blocker…
Design
RCT, Randomly assigned
Follow-up
5 years
Authors
Discussion
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Implication
Supports safe diltiazem discontinuation after year 1 post-CABG; confirms no long-term radial graft patency or outcome benefit from continuation.
Study Design
Type
RCT (n=120)
Multicenter
No
Structured PICO
Does the continuation of chronic calcium channel blocker therapy beyond the first postoperative year improve clinical outcomes or radial artery graft patency in patients with radial artery grafts?
P
Population
120 patients with radial artery grafts and no evidence of ischemia or graft malfunction at 1 year postoperatively, followed for 5 years.
I
Intervention
Continuation of chronic calcium channel blocker therapy with diltiazem (120 mg/d) beyond the first postoperative year for 5 years.
C
Comparator
Suspension of chronic calcium channel blocker therapy beyond the first postoperative year.
O
Outcome
Clinical results, stress myocardial scintigraphy results, and radial artery angiographic status (graft patency) at 5 years.surrogate
Continuing calcium channel blocker therapy beyond one year after radial artery grafting does not improve graft patency or clinical outcomes.
Cite This Study
Gaudino et al. (2001) conducted an RCT in Radial artery grafts for myocardial revascularization (n=120). Chronic calcium channel blocker therapy (diltiazem) vs. Suspension of therapy was evaluated on Clinical and scintigraphic results and radial artery angiographic status. Continuation of chronic calcium channel blocker therapy with diltiazem beyond the first postoperative year did not affect radial artery graft patency or clinical outcomes at 5 years.