Key result
Metabolic syndrome shows no link to carotid plaque in normotensive and prehypertensive individuals.
Why the study?
Is metabolic syndrome associated with an increased risk of carotid atherosclerosis in normotensive and prehypertensive individuals?
Cross-Sectional (n=851)
No
Is metabolic syndrome associated with an increased risk of carotid atherosclerosis in normotensive and prehypertensive individuals?
Metabolic syndrome is not significantly associated with carotid atherosclerosis in individuals with optimal or prehypertensive blood pressure, suggesting that blood pressure control is the primary driver of atherosclerosis prevention in this population.
Answers are grounded in this paper and cite their sources.
Metabolic syndrome may not independently raise carotid atherosclerosis risk in normotensives; leaves open its added value beyond traditional factors in prehypertension.
AIM: We have investigated whether metabolic syndrome is a risk factor for carotid atherosclerosis also in normotensive or prehypertensive individuals. METHODS: We analyzed the data from 851 subjects who had a blood pressure of less than 140/90 mmHg and were not taking antihypertensive medication. Metabolic syndrome was defined according to three different criteria: Japan criteria (Japan-MetS); those of the National Cholesterol Education Program (NCEP)-Adult Treatment Panel III (ATP III) (NCEP-MetS); and modified NCEP-ATP III criteria in which body mass index was used as a surrogate for waist circumference (modified NCEP-MetS). RESULTS: Japan-MetS, NCEP-MetS, and modified NCEP-MetS were found, respectively, in 1%, 4%, and 4%, of women, and in 10%, 5%, and 9%, of men. After the adjustment for gender and age, the association between MetS and carotid atherosclerosis did not reach statistical significance. CONCLUSION: Although the number of enrolled subjects was relatively small, these data may further support the importance of controlling blood pressure within the optimal range for the purpose of preventing atherosclerosis in individuals with metabolic syndrome.
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Ishizaka et al. (2007) conducted a cross-sectional in Carotid atherosclerosis (n=851). Metabolic syndrome vs. Absence of metabolic syndrome was evaluated on Carotid plaque (OR 1.62, 95% CI 0.84-3.11, p=0.15). Metabolic syndrome was not associated with carotid plaque in normotensive and prehypertensive individuals after adjusting for age and sex.
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