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A full account of the evolution of a convergent total synthesis of gonytolide C is reported. The assembly of the natural product core relies on a Horner–Wadsworth–Emmons (HWE) olefination followed by an intramolecular oxa‐Michael addition. Robust and efficient preparations of both HWE coupling partners were established. The synthesis enabled further investigation of an asymmetric oxa‐Michael cyclisation to prepare gonytolide C, demonstrating the utility of this strategy for synthesis of 2,2‐disubstituted chromanones.
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Li et al. (2016) studied this question.
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