Key result
RyR2 stabilizers correct abnormal calcium leak driven by defective receptor unzipping in HF and arrhythmias.
Normalizing ryanodine receptor (RyR) function by correcting defective domain interactions may serve as a novel therapeutic target for heart failure and lethal arrhythmias.
RyR2 stabilizers merit preclinical testing as a target; leaves open clinical translation for heart failure and arrhythmias.
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Yano et al. (2012) conducted a review in Heart failure and lethal arrhythmia. RyR2 stabilizers (e.g., JTV519, dantrolene) was evaluated. Defective inter-domain interactions (unzipping) within the ryanodine receptor (RyR2) cause abnormal calcium leak in heart failure and lethal arrhythmias, which can be corrected by RyR2 stabilizers.
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