Key result
ChAdOx1 nCoV-19 vaccine linked to recurrent coronary artery thrombosis despite triple antithrombotic therapy.
Why the study?
Evidence has emerged regarding the association between the ChAdOx1 nCoV-19 vaccine, platelets, and thrombosis manifesting in thrombotic thrombocytopaenia.
Case Report (n=1)
No
This case highlights a potential association between the ChAdOx1 nCoV-19 vaccine and recurrent coronary thrombosis that is refractory to triple antithrombotic therapy.
Does not warrant practice changes; leaves open a possible ChAdOx1 nCoV-19 link to refractory coronary thrombosis for prospective study.
Background: Vaccines remain the only viable and safe option to control transmission and minimise disease sequelae during the COVID-19 pandemic. Whilst multiple vaccines are available, evidence has emerged regarding the association between the ChAdOx1 nCoV-19 vaccine, platelets and thrombosis, manifesting in thrombotic thrombocytopaenia. Case Summary: We report a case of recurrent coronary artery thrombosis on triple antithrombotic therapy, namely aspirin, clopidogrel, and continuous intravenous heparin, nine days after the ChAdOx1 nCoV-19 vaccine, in a 63-year-old female with no significant history of cardiovascular disease. Conclusion: This case may suggest that the association between platelets, SARS-CoV-2, the ChAdOx1 nCoV-19 vaccine, and coronary thrombosis may remain incompletely understood and warrants further study. Clinicians should remain on high alert if presented with similar circumstances.
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Crane et al. (2022) conducted a case report in Recurrent Coronary Artery Thrombosis (n=1). ChAdOx1 nCoV-19 vaccination was evaluated on Recurrent coronary artery thrombosis. A 63-year-old female experienced recurrent coronary artery thrombosis on triple antithrombotic therapy nine days after receiving the ChAdOx1 nCoV-19 vaccine, suggesting a possible association.
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