What question did this study set out to answer?

To identify the specific microvascular site where venous air emboli lodge in the pulmonary circulation and determine the physiological mechanism of their elimination.

November 1, 1989Journal of Applied Physiology

Fate of air emboli in the pulmonary circulation

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Authors

RPRobert G. PressonIndiana University School of Medicine KKK. R. KirkXerox (United States)KHKenneth A. HaselbySidney & Lois Eskenazi Hospital

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Implication

Experimental animal study reveals venous air emboli lodge in pulmonary arterioles and clear via diffusion in anesthetized dogs, indicating direct alveolar elimination independent of blood flow.

Key Points

To identify the specific microvascular site where venous air emboli lodge in the pulmonary circulation and determine the physiological mechanism of their elimination.
Injected venous air emboli into anesthetized dogs and recorded their behavior within the pulmonary microcirculation using in vivo microscopy.
Measured changes in bubble radius to compare bubble elimination rates under normal perfused conditions versus nonperfused conditions induced by balloon occlusion of lobar blood flow.
Calculated theoretical elimination rates using the Fick equation for molecular diffusion across the arteriolar wall into alveolar spaces.
Small intravenous bubbles lodged exclusively within pulmonary arterioles and were directly eliminated from that anatomical site.
Bubble volume decreased at identical rates under both perfused and nonperfused vascular conditions, demonstrating that bubble clearance is independent of regional blood flow.
Elimination rates calculated using the Fick equation for molecular diffusion through the arteriolar wall into adjacent alveoli nearly matched experimentally observed clearance rates.

Cite This Study

Presson et al. (1989) studied this question.

synapsesocial.com/papers/6aa7936e91938538a9fd9dfd https://doi.org/10.1152/jappl.1989.67.5.1898

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Implication

Experimental animal study reveals venous air emboli lodge in pulmonary arterioles and clear via diffusion in anesthetized dogs, indicating direct alveolar elimination independent of blood flow.

Fate of air emboli in the pulmonary circulation

Discussion

Member takes

Implication

Key Points

Cite This Study

Fate of air emboli in the pulmonary circulation

Discussion

Member takes

Implication

Key Points

Cite This Study

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