Key result
MDAP microarray platform accurately detects viral single base changes at ~0.3% frequency.
The SBE-based microarray technique provides a scalable and cost-effective method to investigate dynamic changes in complex viral populations at frequencies below 1%.
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May advance variant tracking in viral quasispecies; leaves open clinical adoption pending prospective validation.
Webster et al. (2009) studied Viral population genetics. Mutation Distribution Analysis of Populations (MDAP) microarray was evaluated on Detection threshold for single base changes. The MDAP microarray platform accurately detected single base changes present at 0.3-1% frequency in a complex viral population, providing a scalable complement to sequencing methodologies.
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