Key result
Inhaling 5% CO2 induces ~2.4-fold greater reactivity in the MCA compared to retinal vessels.
Why the study?
Does the vascular response to CO2 vary among cerebral, ocular, and mesenteric vessels?
Population
70 subjects
Design
Cross-sectional
Follow-up
3 minutes
Authors
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Vascular CO2 reactivity varies regionally, absent in SMA; leaves open whether inter-individual correlations inform clinical monitoring.
Cross-Sectional (n=70)
No
Does the vascular response to CO2 vary among cerebral, ocular, and mesenteric vessels?
Absolute Event Rate: 2.2% vs 0.9%
p-value: p=<0.05
The vascular response to CO2 varies significantly across different regional vascular beds, being highest in the middle cerebral artery.
Miyaji et al. (2015) conducted a cross-sectional in Healthy (n=70). Inhalation of CO2-rich air vs. Baseline (resting control) was evaluated on CO2 reactivity (relative change in blood flow velocity per mmHg change in PETCO2) (p=<0.05). Inhalation of 5% CO2-rich air induced a significantly greater CO2 reactivity in the middle cerebral artery (2.2 %/mmHg) compared to the retinal artery (0.9 %/mmHg) and retinal and choroidal vessels.
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