Loxiglumide abolishes the effects of intraduodenal oleic acid on gastric motility and emptying in the pig

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AbstractThe role of cholecystokinin in mediating the effects of intraduodenal fat infusion on gastric motility and gastric emptying and the pattern of transpyloric flow was evaluated in conscious pigs. Concurrent measurements of antropyloroduodenal motility with an eight‐channel sleeve/sidehole catheter, transpyloric flow and gastric emptying after instillation of 1000 ml of saline into the stomach, were made during intraduodenal infusion of either normal saline or oleic acid at 5 ml min−1. Studies with intraduodenal oleic acid were performed with and without intravenous infusion of loxiglumide (30 mg kg−1intravenous bolus 15 min before intraduodenal oleic acid, followed by intravenous infusion of 10 mg kg−1h−1), Intraduodenal oleic acid was associated with stimulation of isolated pyloric pressure waves (P < 0.05), inhibition of antral pressure waves (P < 0.05), reduced pulsatile transpyloric flow (P < 0.05) and retardation of gastric emptying (P < 0.05). when compared to intraduodenal saline. Loxiglumide prevented retardation of gastric emptying by intraduodenal oleic acid (P < 0.05), and maintained it at values that were not significantly different from saline. After loxiglumide there were more antral pressure waves (P < 0.05) and less isolated pyloric pressure waves (P < 0.05) when compared to oleic acid. These results indicate that the effects of intraduodenal oleic acid on gastric and pyloric motility, and gastric emptying are largely mediated by CCK‐dependent mechanisms.