Key result
Discharge statins linked to ~45% lower 1-year mortality in myocardial injury after noncardiac surgery.
Why the study?
MINS strongly predicts mortality regardless of symptoms, but anticoagulation is the only established treatment, leaving the association between statin treatment and mortality unestablished.
Does statin treatment at discharge reduce mortality in adult patients with myocardial injury after noncardiac surgery?
Population
5,109 adult patients discharged after the occurrence of MINS
Comparison
Statin prescription at discharge vs no statin
Design
Observational cohort study with inverse probability treatment weighting
Follow-up
1-year and overall
Authors
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May support statin consideration at discharge in MINS; hypothesis-generating and requires RCTs before practice change.
Observational (n=5,109)
No
Does statin treatment at discharge reduce mortality in adult patients with myocardial injury after noncardiac surgery?
Hazard Ratio: 0.55 (95% CI 0.41–0.74)
Absolute Event Rate: 6.1% vs 13.3%
p-value: p=<0.001
Statin prescription at discharge is associated with significantly lower 1-year and overall mortality in patients who experience myocardial injury after noncardiac surgery.
Park et al. (2020) conducted an observational in Myocardial injury after noncardiac surgery (MINS) (n=5,109). Statin prescription at discharge vs. No statin prescription at discharge was evaluated on 1-year mortality (HR 0.55, 95% CI 0.41-0.74, p=<0.001). Statin prescription at discharge was associated with a significantly lower risk of 1-year mortality compared to no statin in patients with myocardial injury after noncardiac surgery (HR 0.55).
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