What does this research mean for the field?

Underweight and obese individuals are more likely to be diagnosed with an anxiety disorder compared to normal-weight individuals, displaying a U-shaped association that varies significantly across sex, race, and age groups. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

October 31, 2016Clinical Practice and Epidemiology in Mental HealthOpen Access

Associations Between Anxiety Disorder Diagnoses and Body Mass Index Differ by Age, Sex and Race: A Population Based Study

Q: What are the key findings of this study?

Underweight (OR 1.31) and obese (OR 1.09) individuals were significantly more likely to have an anxiety diagnosis compared to normal weight individuals, demonstrating a U-shaped association.

Q: What is the clinical evidence from this study?

Study design: Cross-Sectional. Population: Anxiety disorders and obesity (n=75958). Intervention: Underweight (BMI < 18.5) and Obese (BMI ≥ 30) categories vs. Normal weight (18.5 ≤ BMI < 25). Primary outcome: Any anxiety disorder diagnosis (OR 1.31, 95% CI 1.06, 1.63, p=<0.0001).

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Key result

Underweight and obesity are linked to higher anxiety risk, increasing ~31% for underweight individuals.

OR 1.31
95% CI 1.06, 1.63
P<0.0001
n=75,958

Population

75,958 adults ages 18-85 residing in Olmsted County, MN in 2009 with available height and weight data…

Design

Cross-sectional

Authors

RDRamona S. DeJesusCommunity Care CBCarmen Radecki BreitkopfMayo Clinic in Florida JEJon O. EbbertMayo Clinic

Discussion

Member takes

Overview

May inform anxiety screening by BMI category; leaves open causality and intervention effects pending longitudinal data.

Study Design

Type

Cross-Sectional (n=75,958)

Multicenter

Structured PICO

Population

75,958 adults aged 18-85 residing in Olmsted County, MN, were evaluated to determine the association between body mass index categories and diagnosed anxiety disorders.

Outcome

Association between diagnosed anxiety disorders and BMI categories (underweight, normal weight, overweight, obese)

Main Result

Odds Ratio: 1.31 (95% CI 1.06–1.63)

p-value: p=<0.0001

Anxiety disorders have a U-shaped association with BMI, being more prevalent in underweight and obese individuals, though this relationship varies significantly by age, sex, and race.

Limitations

ICD code diagnoses were derived from any visit time with no knowledge of who made the diagnosis, potentially leading to under- or over-diagnosis.
Lack of data on possible confounding factors such as socioeconomic status and psychotropic medication usage.
Did not adjust for co-morbid depression, which is highly correlated with anxiety.
Cross-sectional nature of the study limits causal inference.
Findings from Olmsted County may not be generalizable to other populations with different socioeconomic or racial/ethnic compositions.
ICD code diagnoses derived from any visit time with no knowledge of who made the diagnosis
lack of data on confounding factors such as socioeconomic status and psychotropic medication usage
did not adjust for depression
cross-sectional nature
may not be generalizable to other populations

Cite This Study

DeJesus et al. (2016) conducted a cross-sectional in Anxiety disorders and obesity (n=75,958). Underweight (BMI < 18.5) and Obese (BMI ≥ 30) categories vs. Normal weight (18.5 ≤ BMI < 25) was evaluated on Any anxiety disorder diagnosis (OR 1.31, 95% CI 1.06, 1.63, p=<0.0001). Underweight (OR 1.31) and obese (OR 1.09) individuals were significantly more likely to have an anxiety diagnosis compared to normal weight individuals, demonstrating a U-shaped association.

synapsesocial.com/papers/6aa7a39d8ef0a7de2a8a774c https://doi.org/10.2174/1745017901612010067

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October 31, 2016Clinical Practice and Epidemiology in Mental HealthOpen Access

Associations Between Anxiety Disorder Diagnoses and Body Mass Index Differ by Age, Sex and Race: A Population Based Study

View Full Paper

Ask AI

Bookmark

Key result

Underweight and obesity are linked to higher anxiety risk, increasing ~31% for underweight individuals.

OR 1.31
95% CI 1.06, 1.63
P<0.0001
n=75,958

Population

75,958 adults ages 18-85 residing in Olmsted County, MN in 2009 with available height and weight data…

Design

Cross-sectional

Authors

RDRamona S. DeJesusCommunity Care CBCarmen Radecki BreitkopfMayo Clinic in Florida JEJon O. EbbertMayo Clinic

Discussion

Member takes

Overview

May inform anxiety screening by BMI category; leaves open causality and intervention effects pending longitudinal data.

Study Design

Type

Cross-Sectional (n=75,958)

Multicenter

Structured PICO

Population

75,958 adults aged 18-85 residing in Olmsted County, MN, were evaluated to determine the association between body mass index categories and diagnosed anxiety disorders.

Outcome

Association between diagnosed anxiety disorders and BMI categories (underweight, normal weight, overweight, obese)

Main Result

Odds Ratio: 1.31 (95% CI 1.06–1.63)

p-value: p=<0.0001

Anxiety disorders have a U-shaped association with BMI, being more prevalent in underweight and obese individuals, though this relationship varies significantly by age, sex, and race.

Limitations

ICD code diagnoses were derived from any visit time with no knowledge of who made the diagnosis, potentially leading to under- or over-diagnosis.
Lack of data on possible confounding factors such as socioeconomic status and psychotropic medication usage.
Did not adjust for co-morbid depression, which is highly correlated with anxiety.
Cross-sectional nature of the study limits causal inference.
Findings from Olmsted County may not be generalizable to other populations with different socioeconomic or racial/ethnic compositions.
ICD code diagnoses derived from any visit time with no knowledge of who made the diagnosis
lack of data on confounding factors such as socioeconomic status and psychotropic medication usage
did not adjust for depression
cross-sectional nature
may not be generalizable to other populations

Cite This Study

synapsesocial.com/papers/6aa7a39d8ef0a7de2a8a774c https://doi.org/10.2174/1745017901612010067

Also Consider

Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context:

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