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September 11, 2026Circulation Cardiovascular Interventions

Transcatheter Edge-to-Edge Repair in Older Adults With Mitral and Tricuspid Valve Disease

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Why the study?

Older adults with mitral and tricuspid regurgitation are often ineligible for surgery, making it necessary to examine transcatheter edge-to-edge repair and geriatric cardiology integration.

Design

Review

Key result

Transcatheter edge-to-edge repair is a safe and effective alternative for older adults with mitral and tricuspid valve disease who are ineligible for surgical repair.

Authors

RARadwan AlkhatibTHTaha HatabMAMaha Alfaraidhy

Discussion

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Overview

Supports TEER for inoperable older adults with mitral-tricuspid disease; extends RCT evidence to multivalve repair.

Structured PICO

P
Population
Older adults with clinically significant mitral regurgitation and tricuspid regurgitation who are ineligible for surgical repair due to frailty, multimorbidity, and coexisting geriatric conditions
I
Intervention
Transcatheter edge-to-edge repair (TEER) integrated with geriatric cardiology tools

Integration of geriatric assessment tools is critical to optimize outcomes of transcatheter edge-to-edge repair in older adults with mitral and tricuspid valve disease.

Limitations

  • Inconsistent characterization of frailty and cognitive status in clinical trials
  • Limited transcatheter edge-to-edge repair-specific tools to assess age-associated risks
  • Scarcity of long-term data on functional independence and quality-of-life end points
  • inconsistent characterization of frailty and cognitive status in clinical trials
  • limited transcatheter edge-to-edge repair-specific tools to assess age-associated risks
  • scarcity of long-term data on functional independence and quality-of-life end points

Cite This Study

Alkhatib et al. (2026) conducted a review in Mitral and tricuspid valve disease. Transcatheter edge-to-edge repair was evaluated. Transcatheter edge-to-edge repair is a safe and effective alternative for older adults with mitral and tricuspid valve disease who are ineligible for surgical repair.

synapsesocial.com/papers/6aa7a71508fdee739d2bd9ebhttps://doi.org/10.1161/circinterventions.126.017207
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