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September 14, 2026American Heart Journal Plus Cardiology Research and PracticeOpen Access

Mortality and clinical outcomes in peripartum cardiomyopathy: A systematic review and meta-analysis

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Population

60 studies comprising 44,922 women with peripartum cardiomyopathy (PPCM).

Design

Meta-analysis

Key result

Peripartum cardiomyopathy was associated with a pooled all-cause mortality rate of 7% (95% CI 5-9%), with substantial variability across geographic regions and clinical settings.

Authors

RGResha Reya GanthanFRFrancesco Rotatori

Discussion

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Overview

Guides maternal risk counseling in PPCM; reinforces pooled estimates of mortality and recovery from observational data.

Key Points

  • To evaluate pooled all-cause mortality and heart failure hospitalization rates in women diagnosed with peripartum cardiomyopathy.
  • Systematic review and meta-analysis searching PubMed, Embase, and Web of Science from inception through April 2026.
  • Included 60 studies comprising 44,922 patients reporting all-cause mortality or heart failure hospitalization.
  • Pooled event rates were estimated using a random-effects model with logit transformation.
  • The pooled all-cause mortality rate was 7% (95% CI 5–9%), with marked heterogeneity (I² = 96.4%) and rates spanning 0% to over 25% across regions.
  • Heart failure hospitalization was documented in three studies, yielding a pooled event rate of 11% (95% CI 1–63%).

Study Design

Type

Meta-Analysis (n=44,922)

Structured PICO

P
Population
44,922 women with peripartum cardiomyopathy across 60 studies evaluating all-cause mortality and heart failure hospitalization.
O
Outcome
All-cause mortality and/or heart failure hospitalizationhard clinical

Peripartum cardiomyopathy carries a significant 7% pooled all-cause mortality rate, highlighting the critical need for improved recognition and standardized longitudinal cardiovascular care.

Limitations

  • Substantial heterogeneity (I2 = 96.4%)
  • Limited evidence base for heart failure hospitalization
  • Substantial heterogeneity

Cite This Study

Ganthan et al. (2026) conducted a meta-analysis in Peripartum cardiomyopathy (n=44,922). Peripartum cardiomyopathy was evaluated on all-cause mortality (95% CI 5-9). Peripartum cardiomyopathy was associated with a pooled all-cause mortality rate of 7% (95% CI 5-9%), with substantial variability across geographic regions and clinical settings.

synapsesocial.com/papers/6aa7afef79e9260bc85aaccfhttps://doi.org/10.1016/j.ahjo.2026.100887
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