Key result
In a meta-analysis of peripartum cardiomyopathy, 40% of patients recovered left ventricular function within six months postpartum, with baseline LVEF ≥ 30% being a major predictor of recovery.
Meta-Analysis (n=1,999)
This review summarizes the epidemiology, risk factors, clinical presentation, and diagnostic pathways for peripartum cardiomyopathy, emphasizing the importance of early diagnosis and differentiation from other causes of pregnancy-associated heart failure.
Highlights geographic incidence disparities in PPCM; leaves open optimal management strategies pending prospective trials.
Despite most pregnant women safely tolerating heart diseases, they remain a leading cause of non-obstetric maternal mortality. Peripartum cardiomyopathy (PPCM) is a serious heart muscle disease caused or aggravated by pregnancy. It imposes significant risks for the development of pregnancy-associated heart failure with an elevated risk of fetomaternal morbidity and mortality. Its incidence has significance geographic variations with considerably higher rates in developing countries. With increased efforts to improve fetomaternal health in disadvantaged populations, there is need to improve the understanding of PPCM including its risk factors, diagnosis and clinical management. This review accumulates current evidence on research and clinical status as well as conducts a meta-analysis of diagnosis and clinical management to advance understanding.
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Aref Albakri (2018) conducted a meta-analysis in Peripartum cardiomyopathy (n=1,999). Peripartum cardiomyopathy diagnosis and management was evaluated on Left ventricular recovery (LVEF > 50%). In a meta-analysis of peripartum cardiomyopathy, 40% of patients recovered left ventricular function within six months postpartum, with baseline LVEF ≥ 30% being a major predictor of recovery.
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