Key result
A 300 mg oral loading dose of aspirin induced maximal platelet inhibition within a median of 30 minutes in healthy volunteers, an effect that was not reversed by ex vivo desmopressin.
Why the study?
Does a 300 mg oral loading dose of aspirin induce rapid platelet inhibition, and does ex vivo desmopressin reverse this effect in healthy volunteers?
Observational (n=10)
No
Does a 300 mg oral loading dose of aspirin induce rapid platelet inhibition, and does ex vivo desmopressin reverse this effect in healthy volunteers?
p-value: p=<0.001
A 300 mg oral loading dose of aspirin induces maximal platelet inhibition within a median of 30 minutes in healthy volunteers, an effect not reversed by ex vivo desmopressin.
To investigate the time to maximal platelet inhibition after an oral loading dose of ASA. The effect of ex vivo reversal platelet inhibition by desmopressin (DDAVP) was also studied.
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Schött et al. (2021) conducted an observational in Healthy volunteers (n=10). Acetylsalicylic acid (Aspirin) vs. Baseline was evaluated on Time to maximal platelet inhibition (ASPItest AUC < 30 U) (p=<0.001). A 300 mg oral loading dose of aspirin induced maximal platelet inhibition within a median of 30 minutes in healthy volunteers, an effect that was not reversed by ex vivo desmopressin.
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