Key result
Random skin biopsy diagnoses intravascular large B-cell lymphoma in 40% of suspected patients.
Why the study?
Random skin biopsy sensitivity for diagnosing intravascular large B-cell lymphoma varies across studies, necessitating evaluation of efficacy and safety of a 20-mm incisional RSB method.
Does 20-mm incisional random skin biopsy facilitate the diagnosis of intravascular large B-cell lymphoma in suspected patients?
Observational (n=15)
No
Does 20-mm incisional random skin biopsy facilitate the diagnosis of intravascular large B-cell lymphoma in suspected patients?
A 20-mm incisional random skin biopsy is a feasible and potentially effective diagnostic tool for intravascular large B-cell lymphoma.
May aid IVLBCL diagnosis in select cases; hypothesis-generating and requires prospective validation before practice change.
Intravascular large B-cell lymphoma (IVLBCL) is a rare subtype of aggressive non-Hodgkin lymphoma characterized by the preferential proliferation of lymphoma cells within small vessels. Random skin biopsy (RSB) has been reported as a useful diagnostic tool for IVLBCL, although its sensitivity varies across studies. We retrospectively evaluated the efficacy and safety of the RSB method used at our institution. Between January 2022 and April 2026, 15 patients underwent RSB. Spindle-shaped incisions approximately 20 mm in length were made to obtain skin specimens containing subcutaneous fat. Six patients were diagnosed with IVLBCL by RSB. In most cases, IVLBCL cells were identified within vessels in the subcutaneous fat. Wider specimens contained a greater number of IVLBCL lesions. Hematoma formation occurred in one patient after RSB, and was successfully managed with supportive care. Our RSB method may facilitate the prompt diagnosis and treatment of patients suspected of having IVLBCL.
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Izumi et al. (2026) conducted an observational in Intravascular large B-cell lymphoma (n=15). 20-mm incisional random skin biopsy was evaluated on Diagnosis of intravascular large B-cell lymphoma. A 20-mm incisional random skin biopsy successfully diagnosed intravascular large B-cell lymphoma in 40% (6 of 15) of suspected patients, with only one case of hematoma formation.
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