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September 14, 2026Journal of Clinical HypertensionOpen Access

Functional Markers of Vascular Aging: Subendocardial Viability Ratio, Augmentation Pressure, and Augmentation Index as Links to Atherosclerotic Cardiovascular Disease Risk

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Why the study?

Do functional hemodynamic parameters (SEVR, AP, Aix@75) correlate with estimated 10-year ASCVD risk in a Chinese population?

Population

3,354 participants aged 18-80 years with left ventricular ejection fraction >55% in a Chinese population.

Design

Cross-sectional

Key result

Functional hemodynamic parameters including SEVR (r=-0.171), AP (r=0.452), and Aix@75 (r=0.236) were independently correlated with estimated 10-year ASCVD risk (p<0.001).

Authors

LYLan YangLWLingxiao WangJMJing Ma

Discussion

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Overview

Correlations of SEVR, AP, and Aix@75 with ASCVD risk are hypothesis-generating; prospective studies needed before clinical adoption.

Key Points

  • To examine the relationship between functional hemodynamic markers of vascular aging and estimated 10-year atherosclerotic cardiovascular disease risk.
  • Enrolled 3,354 Chinese participants aged 18–80 years with left ventricular ejection fraction >55% in a cross-sectional study.
  • Evaluated hemodynamic parameters using pulse wave analysis and calculated 10-year cardiovascular disease risk using the China-PAR model.
  • Identified independent correlates of elevated cardiovascular risk via multivariable logistic regression and stepwise linear regression.
  • Estimated 10-year cardiovascular risk correlated inversely with subendocardial viability ratio (r = -0.171, p < 0.001) and positively with augmentation pressure (r = 0.452, p < 0.001) and heart-rate-corrected augmentation index (r = 0.236, p < 0.001).
  • Subendocardial viability ratio, augmentation pressure, and heart-rate-corrected augmentation index were all identified as independent correlates of estimated 10-year risk in stepwise multivariable linear regression (p < 0.001).

Study Design

Type

Cross-Sectional (n=3,354)

Structured PICO

Do functional hemodynamic parameters (SEVR, AP, Aix@75) correlate with estimated 10-year ASCVD risk in a Chinese population?

P
Population
3,354 Chinese participants aged 18-80 years with left ventricular ejection fraction >55% assessed for functional hemodynamic parameters and 10-year ASCVD risk.
E
Exposure
Assessment of functional hemodynamic parameters (subendocardial viability ratio [SEVR], augmentation pressure [AP], and heart-rate-corrected augmentation index [Aix@75]) by pulse wave analysis
O
Outcome
Correlation with estimated 10-year ASCVD risk (10Y-ASCVDR) using the China-PAR modelsurrogate

Main Result

p-value: p=<0.001

Functional hemodynamic parameters (SEVR, AP, Aix@75) independently correlate with estimated 10-year ASCVD risk, suggesting their potential role as supplementary tools for cardiovascular risk stratification.

Cite This Study

Yang et al. (2026) conducted a cross-sectional in Atherosclerotic cardiovascular disease risk (n=3,354). Functional hemodynamic parameters (SEVR, AP, Aix@75) was evaluated on Estimated 10-year ASCVD risk (10Y-ASCVDR) (p=<0.001). Functional hemodynamic parameters including SEVR (r=-0.171), AP (r=0.452), and Aix@75 (r=0.236) were independently correlated with estimated 10-year ASCVD risk (p<0.001).

synapsesocial.com/papers/6aa7afef79e9260bc85aad06https://doi.org/10.1111/jch.70364
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