Key result
Worse LV-GLS predicts sepsis cardiomyopathy mortality, but inter-vendor variability limits routine ICU use.
Why the study?
The body of evidence and knowledge on the utility, feasibility, and prognostic value of left ventricular global longitudinal strain in sepsis cardiomyopathy is still evolving.
Does left ventricular global longitudinal strain by two-dimensional speckle tracking echocardiography predict mortality in patients with sepsis cardiomyopathy?
Does left ventricular global longitudinal strain by two-dimensional speckle tracking echocardiography predict mortality in patients with sepsis cardiomyopathy?
This review highlights the evolving role and prognostic value of left ventricular global longitudinal strain in managing sepsis cardiomyopathy in the ICU.
GLS may aid mortality risk stratification in sepsis cardiomyopathy; leaves open standardization needs before routine ICU adoption.
Myocardial deformation imaging (strain imaging) is a technique to directly quantify the extent of myocardial contractility and overcomes several of the limitations of ejection fraction. The application of the most commonly used strain imaging method; speckle-tracking echocardiography to patients with sepsis cardiomyopathy heralds an exciting development to the field. However; the body of evidence and knowledge on the utility, feasibility and prognostic value of left ventricular global longitudinal strain in sepsis cardiomyopathy is still evolving. We conducted a review of literature on utility of left ventricular global longitudinal strain in sepsis cardiomyopathy. We discuss the role of left ventricular global longitudinal strain in mortality prediction, utility and limitations of the technique in the context of sepsis cardiomyopathy.
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Velagapudi et al. (2019) conducted a review in Sepsis cardiomyopathy (n=846). Left ventricular global longitudinal strain vs. Left ventricular ejection fraction was evaluated. Left ventricular global longitudinal strain is associated with mortality in sepsis cardiomyopathy, with less negative values predicting worse outcomes, though significant inter-vendor variability and lack of standardization currently limit its routine ICU use.
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