What question did this study set out to answer?

To review preclinical and neuroimaging evidence supporting the hypothesis that endogenous dopamine sensitization contributes to the pathophysiology of schizophrenia.

March 1, 2000Brain Research ReviewsOpen Access

The role of endogenous sensitization in the pathophysiology of schizophrenia: Implications from recent brain imaging studies

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To review preclinical and neuroimaging evidence supporting the hypothesis that endogenous dopamine sensitization contributes to the pathophysiology of schizophrenia.
Synthesized rodent models examining stimulant-induced sensitization of dopamine pathways and its relevance to drug-induced psychosis.
Evaluated clinical positron emission tomography and single-photon emission computed tomography brain imaging studies measuring amphetamine-induced dopamine release across different clinical stages of schizophrenia.
In vivo brain imaging studies indicate that schizophrenia is associated with exaggerated amphetamine-induced dopamine release specifically during clinical deterioration, rather than during clinical stability.
Preclinical evidence shows that prefrontal dopamine projections buffer subcortical dopamine systems, indicating that early neurodevelopmental prefrontal deficits increase susceptibility to sensitization in young adulthood.
Sustained D2 receptor antagonist therapy facilitates extinction of the sensitized dopamine state, while treatment discontinuation creates vulnerability to its re-emergence.

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Implication

Literature review uncovers heightened stimulant-induced dopamine release during acute episodes in schizophrenia, suggesting an endogenous sensitization process driven by prefrontal deficits.

Cite This Study

Marc Laruelle (2000) studied this question.

synapsesocial.com/papers/6aa7b0b8bfbaf8fff057433e https://doi.org/10.1016/s0165-0173(99)00054-5

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Implication

Literature review uncovers heightened stimulant-induced dopamine release during acute episodes in schizophrenia, suggesting an endogenous sensitization process driven by prefrontal deficits.

The role of endogenous sensitization in the pathophysiology of schizophrenia: Implications from recent brain imaging studies

Key Points

Discussion

Implication

Cite This Study

The role of endogenous sensitization in the pathophysiology of schizophrenia: Implications from recent brain imaging studies

Key Points

Discussion

Implication

Cite This Study

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